Repolarization Measurement in Brugada Syndrome

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Inferior and lateral electrocardiographic repolarization abnormalities in Brugada syndrome.

BACKGROUND Repolarization abnormalities in the inferior-lateral leads in Brugada syndrome (BS) have not been systematically investigated. METHODS AND RESULTS 280 patients (age, 41+/-18 years; 168 males) with BS were screened for inferior-lateral repolarization abnormalities. The repolarization abnormalities were classified either as early repolarization pattern or coved > or = 2-mm Brugada pa...

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Overlapping risks of early repolarization and Brugada syndrome.

Over the past 2 decades, we have witnessed major progress toward a better understanding of the Brugada syndrome (BrS) and have gained knowledge of the genetic aspects, pathophysiology, and new management of the syndrome (1–3). However, controversies exist, especially concerning the role of sodium channel mutation and electrophysiological mechanisms underlying the syndrome (2,4), as well as risk...

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The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization.

This Point/Counterpoint presents a scholarly debate of the mechanisms underlying the electrocardiographic and arrhythmic manifestations of Brugada syndrome (BrS), exploring in detail the available evidence in support of the repolarization vs. depolarization hypothesis.

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High-density substrate mapping in Brugada syndrome: combined role of conduction and repolarization heterogeneities in arrhythmogenesis.

BACKGROUND Two principal mechanisms are thought to be responsible for Brugada syndrome (BS): (1) right ventricular (RV) conduction delay and (2) RV subepicardial action potential shortening. This in vivo high-density mapping study evaluated the conduction and repolarization properties of the RV in BS subjects. METHODS AND RESULTS A noncontact mapping array was positioned in the RV of 18 BS pa...

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Electrical storm in patients with brugada syndrome is associated with early repolarization.

BACKGROUND Electrical storms (ESs) in patients with Brugada syndrome (BrS) are rare though potentially lethal. METHODS AND RESULTS We studied 22 men with BrS and ES, defined as ≥3 episodes/d of ventricular fibrillation (VF) and compared their characteristics with those of 110 age-matched, control men with BrS without ES. BrS was diagnosed by a spontaneous or drug-induced type 1 pattern on the...

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ژورنال

عنوان ژورنال: Journal of the American College of Cardiology

سال: 2008

ISSN: 0735-1097

DOI: 10.1016/j.jacc.2008.04.054